Rock-bottom Biarritz slumped to their eighth defeat in nine matches this season when they were defeated 16-12 by Perpignan on Friday.
In an error-hit, scrappy affair, Perpignan grabbed the only try of the night six minutes into the second half when captain and hooker Guilhem Guirado was driven over by his pack.
Welsh full-back James Hook added the conversion for a 13-9 lead after French scrum-half Dimitri Yachvili had kicked Biarritz into a 9-6 lead.
Yachvili then made it four successful kicks in four attempts to pull Biarritz to within a point at 13-12.
He then missed for the first time just after the hour before Hook landed a monster penalty to give Perpignan breathing space at 16-12 and their first away win of the Top 14 season.
Hook had crossed the try-line in the first half but saw his score ruled out for a knock-on.
"We lacked a little strategy, a little ambition," admitted Biarritz centre Benoit Baby.
"We can do good things when we want to, now we need to grit our teeth. The club has lots of ambition."
Biarritz, the five-time French champions, remain bottom of the table, eight points from safety with their only consolation being a losing bonus point from the match.
"It's hard for Biarritz. When you have seen what they did in their great past (three titles since 2002), they are up against it now," said Perpignan fly-half Camille Lopez.
Friday's defeat capped a miserable week for Biarritz.
They had hooker Arnaud Heguy suspended for 20 weeks for threatening the referee in the 24-13 loss to Toulon last month.
Forwards coach Laurent Rodriguez was banned for 12 weeks and president Serge Blanco was also suspended from all rugby activity for four weeks following the same acrimonious defeat.
They also went into Friday's match without experienced backrow forward Imanol Harionordoquy whose knee injury has limited him to just 20 minutes of action all season.