Australia's representation in women's singles at the US Open has ended after Ashleigh Barty went down to Anastasia Pavlyuchenkova on Wednesday, 6-4 6-0.

The Australian wildcard, looking to secure a maiden third round grand slam appearance, initially kept pace with the No.32 seed before Pavlyuchenkova powered up to finish the match in just over an hour.

It is Barty's second comprehensive loss to the Russian this year who now makes her way through to a likely third round meeting with No.3 seed Agnieszka Radwanska.

Barty remains a strong contender in the doubles where the teenager and her partner, fellow Australian Casey Dellacqua, both enjoy rankings inside the top 20.

The pair's winning form this year has included two grand slam finals and a WTA win.

Wildcard James Duckworth, veteran Lleyton Hewitt and Bernard Tomic are the Australians who remain in the men's singles draw.