ROSMALEN, Netherlands (AP) — French Open losing finalist David Ferrer lost his first round match Tuesday at the Topshelf Open, depriving him of valuable practice time on the grass courts of Rosmalen in the week before Wimbledon.

A single service break in the second set was enough for Xavier Malisse of Belgium to beat defending champion and top-seeded Ferrer in straight sets, 7-6 (3), 6-3.

"I think I need to play more on grass to get into it," Ferrer said. "I can now train for a few days in London. I have to stay positive; my focus is now on my first match at Wimbledon."

Ferrer was the top but far from the only seeded player to fall in the first round of the men's draw.

Second-seeded Stanislas Wawrinka bucked the trend by beating Steve Darcis 7-6 (5), 6-4. Darcis was a late replacement for Dutchman Igor Sijsling, who dropped out of the tournament in the morning with a stomach complaint. The only other seeded player to reach the second round was Jeremy Chardy of France, seeded fifth, who beat Lucas Pouille 7-5, 6-4.

The top-seeded woman, 2011 champion Roberta Vinci, had no such problems, brushing aside Kaia Kanepi 6-3, 6-3 in the first match on center court to reach the second round.

Fourth-seeded Kirsten Flipkens rallied from a set down to overcome Francesca Schiavone 3-6, 6-3, 6-0 in the first round while Carla Suarez Navarro advanced to the quarterfinals by beating Sofia Arvidsson 6-3, 6-4.

Benoit Paire was another seeded player who didn't make it past the first round, retiring after losing the first three games of the match to fellow Frenchman Michael Llodra.