A 15-year-old girl from Machans Beach died in hospital after the four-wheel drive she was travelling in crossed onto the wrong side of the Kennedy Highway before crashing in a paddock on the Atherton Tablelands.
Seven other teenagers were on board, two of whom were flown to Townsville with life-threatening injuries.
Police say the 17-year-old driver from Bungalow was not properly licensed.
Officers will question the occupants once their injuries are treated.
A 14-year-old girl is in a critical condition in the intensive care unit at Townsville Hospital and a 15-year-old girl is in a stable condition.