Queensland police say three people have been charged and more arrests are likely after two officers were attacked at a wild party on Brisbane's southside over the weekend.

It began with a birthday party at Acacia Ridge on Saturday night but police say someone posted details about it on Facebook and within an hour more than 250 gatecrashers were there.

Dozens of officers were called to the home after neighbours became concerned about revellers' behaviour.

Two officers suffered serious head injuries after they were pelted with bricks and bottles.

One of the officers spent the night in hospital with a fractured eye socket and the other received a number of stitches.

The partygoers also attacked a Brisbane City Council bus, causing thousands of dollars in damage.

A 24-year-old man from Runcorn on Brisbane's southside has been charged with going armed to cause fear and threatening violence.

Two boys, aged 14 and 15, have been charged with a string of offences including grievous bodily harm, wilful damage, affray and obstructing police.

The pair are expected to be dealt with in a juvenile court.

Police say they expect to lay more charges.