Brisbane real estate agent Gerard Baden-Clay will face a committal hearing on Monday, with his defence team expected to argue his wife may have taken her own life.

Baden-Clay is charged with murdering Allison Baden-Clay and interfering with her body, which was found on the banks of a creek 10 days after she vanished in April last year.

Baden-Clay told police the mother of three failed to return to their Brookfield home after going on a late night walk.

But prosecutors will argue the real estate agent was in financial trouble and stood to gain almost a $1 million from his wife's death, including $760,000 from insurance policies.

More than 40 witnesses are expected to be called during the committal hearing.

Baden-Clay made a bail application in December, which was unsuccessful despite his barrister, Peter Davis SC, arguing a new toxicology report suggested his wife had taken her own life.

A magistrate will be asked to test the strength of the crown case and rule on whether there's sufficient evidence to send the matter to trial in the Supreme Court in Brisbane.

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