Victorian drivers caught with a cocktail of drugs and alcohol in their system could soon be fined almost $3000.

Police Minister Peter Ryan said drivers with a blood alcohol concentration of more than 0.05 who had also taken drugs would be charged with a new offence.

"It is a deterrent and they ought to take heed of it," he said.

"If they're stupid enough to do it then they'll be off the road."

Mr Ryan said people charged with the new offence could be fined $2800 and have their licences cancelled for at least one year.

Anyone caught with a blood alcohol reading in excess of 0.1 would have their car impounded for 30 days, as well as have their licence suspended.

Mr Ryan said legislation effecting the changes would be introduced into the parliament as soon as possible.

Assistant Commissioner Robert Hill said tougher measures against drug and alcohol-affected drivers would reduce carnage on the roads.

"This is about saving lives. This about reducing carnage on our roads," Mr Hill said.

He said risky behaviour was compounded when drivers combined drugs and alcohol.

"They need to take responsibility for their actions. This is a deliberate and reckless act on their part," he said.

"These poor choices can lead to tragic consequences."

The tougher approach was aimed at deterring people from making wrong choices, he said.

He said research showed between 2008 and 2011, 12 per cent of those killed on the road were affected by drugs or alcohol.