A sign on the door says Jameson Tavern is "closed until further notice," but offers no explanation and apologizes for any inconvenience.
It was built in 1779 and was a private residence until being converted into an inn and tavern in 1801.
On its website, Jameson Tavern says it is the site of the signing of documents declaring Maine's independence from Massachusetts in 1820.
Attempts to reach the current owner have been unsuccessful.
The building that houses the tavern as well as another business is currently for sale for $1.85 million.