Football clubs should come clean to their fans about any drug use by their players, Prime Minister Julia Gillard says.
Police, the Australian Sports Anti-Doping Authority (ASADA), the AFL and NRL have launched their own investigations.
Justice Minister Jason Clare said on Sunday both the AFL and NRL had been made aware of the clubs involved.
Both codes had asked for permission to inform the clubs under investigation and the ACC had agreed, Mr Clare said.
"Then it will be up to the clubs to put their hand up and say yes, we are one of the clubs that are affected by this information," he told ABC television on Sunday.
Ms Gillard said fans were anxious to know about the circumstances of their own club.
"So I would say to clubs, please come clean. Make sure that you tell your fans what is going on," the prime minister told reporters in New Zealand.
"For clubs who have absolutely nothing to hide then it will come as a great relief to fans to know that.
"For clubs who have had problems, then it's better off to step forward and be very clear about that."
Mr Clare said the ACC could not identify individuals or organisations that it had criminal intelligence on.
"But the organisations can put their own hand up and the NRL and the AFL have done that over the last few days," he said.
The minister said once the clubs were alerted they could then seek advice from the ACC.
Fans wanted to know if their club was affected, he said.
"The veil of suspicion is hanging over all clubs," he said..
"Silence is not going to be the solution here and I encourage all clubs that are affected to put their hand up and work with the authorities to get this out of the game."
Mr Clare said the investigation was not limited to the AFL and NRL but had focused on the two codes and the use of peptides and hormones.