A man has been charged with fleeing the scene of a fatal crash in Perth's southeastern suburbs that closed Tonkin Highway and raised the state's road toll to 26.

The crash overnight occurred at the intersection of the highway and Gosnells Road East in Orange Grove.

A 21-year-old woman died, while the other driver is alleged to have fled the scene.

Police said the woman had been attempting to turn right into Gosnells Road West from Tonkin Highway when her orange Holden Commodore sedan was struck by a white Holden Commodore sedan travelling north on Tonkin Highway.

It is alleged the man was the driver of the white Commodore.

Major Crash investigators confirmed they had charged a 20-year-old man with failing to stop after an accident and failing to report an accident.

He is due to appear in the Armadale Magistrates Court on February 21.

On Sunday, Police Minister Liza Harvey made an impassioned plea to all drivers to take more care of themselves and others while on the road, describing the road toll for the year so far as "horrific".