A man walks past an electric stock price indicator in Tokyo, Wednesday, Jan. 16, 2013. Japan’s benchmark index toppled off a 32-month high Wednesday after its currency’s downward slide went into reverse. (AP Photo/Shizuo Kambayashi)

Oncolytics details broader use for Reolysin

Published: 03:54:07 PM, Mon 28 January 2013 UTC

Shares of Oncolytics Biotech Inc. climbed Monday after the drug developer said its lead product Reolysin may have a broader use as a potential cancer treatment.

The Canadian company released results from an early-stage study of the drug as a possible treatment of colorectal cancer that has spread. It said patients taking Reolysin in combination with a common chemotherapy regimen called Folfiri had an overall progression-free survival of 7.4 months.

Progression-free survival measures the time before a disease progresses or the patient in the study dies.

The study delivered a compelling result by showing that the disease had either slowed or stabilized in about half the patients, Stifel Nicolaus analyst Brian Klein said. He also said the progression-free survival time was compelling too, but he noted that the study size was small, with only 21 patients enrolled.

Klein also said the result shows the drug appears safe and well-tolerated, and it gives a reason to continue clinical study.

Oncolytics said it will continue testing the drug in colorectal cancer patients. It had presented preliminary results from the small study at a recent gastrointestinal cancers symposium in San Francisco.

The drugmaker currently has no drugs on the market. Reolysin, its most advanced product, also is in late-state testing as a potential treatment for head and neck cancers.

Reolysin is based on a common virus called the respiratory enteric orphan virus, or reovirus. Oncolytics says most adults have been exposed to the virus and it usually has no symptoms. Reolysin is designed to infect and destroy cancer cells. The company says the body's immune response stops the reovirus from replicating in healthy cells, but in cancer cells with specific mutations, the antiviral response is not effective.

U.S.-traded shares of Oncolytics rose 2 percent, or 7 cents, to $3.46 in Monday morning trading while broader trading indexes were relatively flat.

Tags: reolysin, oncolytics, oncolytics biotech inc., brian klein, health, breast cancer, study, san francisco, broader trading indexes, chemotherapy, cancer, oncology, infectious disease, drug, immune system, preliminary results, stifel nicolaus analyst, u.s.-traded shares, drug developer, canadian company, progression-free survival, potential cancer treatment, colorectal cancer, monday morning trading, advanced product, cancer cells, enteric orphan virus, common virus, reovirus, healthy cells, antiviral response, specific mutations, neck cancers, possible treatment, small study, lead product reolysin, common chemotherapy regimen, overall progression-free survival, colorectal cancer patients, progression-free survival time, recent gastrointestinal cancers, oncolytics details, compelling result, early-stage study, reolysin in combination with a, study size, clinical study, late-state testing, potential treatment, mutation

Close
Loading
Close